Laurent Koscielny is expected to miss the match after suffering a foot injury against Valencia on Thursday in the Europa League semi-final first leg.
He was forced to leave the field late on as the Gunners put one foot in the final with a 3-1 victory.
While there are no guarantees they will reach Baku or win the competition, Emery can’t afford to let Arsenal’s chase of the top four slip.
Securing the return of Champions League football will prove key for this summer’s budget and will help attract top players.
Nacho Monreal is expected to return to the fold, he was the man to replace the injured Frenchman in midweek.
Sokratis Papastathopoulos and Shkodran Mustafi will make up the rest of the back three, although Emery could call on Konstantinos Mavropanos if he wants to freshen things up with the trip to the Mestalla in mind.
Ainsley Maitland-Niles will not be available for the clash after being sent off in last week’s 3-0 defeat at Arsenal.
Emery is expected to bring Stephan Lichtsteiner in at right-back, although Carl Jenkinson will also be waiting in the wings for another rare opportunity.
Sead Kolasinac will keep his place at left wing-back with Lucas Torreira reinstated into the line-up alongside Granit Xhaka in midfield.
Mesut Ozil is set to feature in the No 10 role should Emery play 3-4-1-2.
This game would have been Aaron Ramsey’s last match at the Emirates but he has now been ruled out for the rest of the season with a hamstring problem.
Alexandre Lacazette and Pierre-Emerick Aubameyang are expected to lead the line, as they did so expertly in midweek.