Young underdogs Ajax wasted no time at all in stamping their authority on the contest and it was no surprise to see them take the lead in the 15th minute.
Van de Beek, involved earlier in the move when he brilliantly flicked the ball away from Dele Alli, drifted between Jan Vertonghen and Danny Rose, collected Ziyech’s pass and calmly placed his finish beyond Lloris.
There was no need for a VAR check as replays showed the midfielder was marginally onside and Ajax kept their foot on the accelerator, with Rose almost slicing into his own net and Van de Beek being denied by Lloris at his near post following a fine dummy.
Spurs eventually responded and looked most threatening from free-kicks, Fernando Llorente and then Toby Alderweireld both directing Kieran Trippier set-pieces off target.
Yet, already shorn of the injured Harry Kane and suspended Son Heung-min, they were forced to reorganise again when a battered and bloodied Vertonghen had to come off having collided with Alderweireld’s head.
That enforced introduction of Moussa Sissoko gave Spurs more midfield control and Alli twice came close before the hour, firing a half volley straight at Andre Onana and then heading over.
Yet opportunities such as those who were too infrequent from the hosts’ perspective as their defensive work in chasing Ajax early on appeared to take its toll.
And they were fortunate the Dutch club did not leave London with a greater advantage as Neres’ placed finish from a counter-attack with 12 minutes to go came back off a post with Lloris motionless.