Ole Gunnar Solskjaer will be without Ashley Young who picked up a red card in Manchester United’s defeat to Wolves last time out.
Luke Shaw received his tenth booking of the season in that game as well, meaning he’s serving the first of a two-match ban.
Shaw will also miss the return leg against Barcelona in the Champions League quarter-finals after picking a yellow in the first leg.
Marcos Rojo is expected to earn just his second start of the Premier League season at left-back and will hope to impress with a place against Barcelona up for grabs.
Antonio Valencia and Matteo Darmian are both unavailable due to injury while Eric Bailly is also doubtful following a head injury on international duty.
Nemanja Matic and Ander Herrera were both not fit to play on Wednesday and it remains unclear whether they will have recovered in time to face the Hammers.
However, Alexis Sanchez should be included in the squad after recovering from a knee injury.
Speaking after the Barcelona match, Solskjaer said: “He has done lots of injury work and is now injury free.
Now he’ll step up and train with the team. He will probably be in the squad for West Ham on Saturday and let’s see how much, and if he plays.”
Fred and Paul Pogba are likely to contuse in midfielder together, alongside Scott McTominay, who impressed against Barca.
Marcus Rashford will likely be rested following 85 minutes of action in midweek.
That, coupled with an ankle knock he picked up, should see Anthony Martial replace him in the starting line-up.