The national side announced on social media the former Stoke man is out with ‘inflammation in the pubic area’.
The 27-year-old will miss matches against Georgia and Denmark as a result.
Thankfully no further detail was given and Shaqiri will now focus on getting fit for the business end of the season with Liverpool.
he official Twitter account of Switzerland posted: “The national team A must renounce the services of Xherdan Shaqiri in the games against Georgia and Denmark.
“Shaqiri suffers from an inflammation of the pubic area.
“Shaqiri left the retreat tonight.
“His substitute will be announced Tuesday #GEOSUI #SUIDEN.”
Gibraltar and the Republic of Ireland join Switzerland, Georgia in Denmark in Group D in the race to qualify for Euro 2020.
Switzerland are already guaranteed at least a play-off place due to their performance in the Nations League.
Shaqiri has impressed for Liverpool this season, netting six goals and providing three assists in all competitions.
His form has tailed off recently though and Jurgen Klopp hasn’t used him in his last four Premier League matches.
In fact, Shaqiri hasn’t started a match since January 30.
Liverpool will hope they don’t suffer any significant injuries with many key players away on international duty.
The likes of Roberto Firmino, Virgil van Dijk and Sadio Mane are all away from Anfield for the next couple of weeks.
Liverpool return to action after the international break against Tottenham on Sunday, March 31.
The Reds currently sit top of the Premier League, two points clear of Manchester City having played one more game.