Inter who has won the Champions League three times; two back to back in 1964 and 1965 and then another in 2010 but to their amazement, they have been beaten at home Germany side, Eintracht Frankfurt.
Inter Milan were knocked out of the Europa League at the San Siro as Luka Jovic’s first half goal took Eintracht Frankfurt into the quarter-finals.
The 21-year-old Serbia forward raced clear to lob the ball over Inter keeper Samir Handanovic.
Inter, who were without Mauro Icardi, introduced 16-year-old Sebastiano Esposito, as they chased the game.
However, Frankfurt held on to reach their first quarter-final of a major European competition since 1994-95.
Luciano Spalletti’s Inter side currently reside in fourth position in Serie A, with Frankfurt in fifth position in the Bundesliga.
Meanwhile Slavia Prague shocked Sevilla to win 4-3 after extra-time and 6-5 on aggregate in a thrilling contest.
Napoli lost 3-1 to RB Salzburg in Austria but held on to progress to the quarter-finals 4-3 on aggregate.
Munas Dabbur, Fredrik Gulbrandsen and Christoph Leitgeb scored for last term’s semi-finalists but Arkadiusz Milik’s early goal proved decisive for the Serie A club.
In Spain, Villarreal progressed after a 2-1 victory over Zenit St Petersburgto complete a comfortable 5-2 aggregate win.
Gerard Moreno and Carlos Bacca scored for the hosts with former Chelsea defender Branislav Ivanovic pulling a goal back late on for the visitors.
Benfica overturned a 1-0 first-leg deficit against Dinamo Zagreb to advance after 3-1 on aggregate.
Substitute Jonas’ goal took the tie into extra-time before further goals from Ferro and Alejandro Grimaldo wrapped up their win.
Goncalo Guedes late goal saw Valencia reach the last eight after a 1-1 draw at FK Krasnodar.
Magomed Suleymanov’s 85th minute goal for the Russian club had looked as though it would take the tie into extra-time.