Barcelona could not convert any of their 25 shots in a goalless Champions League last-16 first-leg draw against Lyon.
Usually so proficient in front of goal, Barca’s Lionel Messi, Luis Suarez and Phillipe Coutinho were all denied by Lyon goalkeeper Anthony Lopes.
Lyon had chances, too, but Marc-Andre ter Stegen brilliantly tipped Martin Terrier’s long-range shot onto the bar.
The return leg takes place at the Nou Camp on Wednesday, 13 March.
Champions Barca are top of La Liga, seven points clear of second-placed Atletico Madrid, but they have not won Europe’s premier competition since 2015 when they defeated Juventus in the final.
Going into this tie, Ernesto Valverde’s side were heavy favourites to progress to the quarter-finals for the 11th consecutive season, but their poor finishing leaves the tie in the balance.
The Catalans have now drawn four of their last five games in all competitions and should have netted twice in the opening four minutes but Ousmane Dembele scuffed off target and Messi dinked a free-kick over.
When Barca did call on Lopes, they found the Lyon number one in superb form, springing high in the second half to tip over Sergio Busquets’ drive, the best of his five saves in the game.
French club Lyon, the only side to beat runaway Ligue 1 leaders Paris St-Germain this season, could have snatched a goal themselves but Houssem Aouar’s strike was pushed away by Germany international Ter Stegen and Memphis Depay screwed a shot wide from the angle.