The Red Devils have found some form domestically, claiming 10 points from the last 12 available to move up to seventh in the table – four points off the top four. But they have plenty of work to do in Europe, having lost to Juve at Old Trafford last time out after a draw with Valencia.
While United don’t need to win at the Allianz Stadium, given they still have games at home to Young Boys and away to Valencia to come, a result in Italy would be massive for Jose Mourinho.
The Portuguese boss has a few injury issues to contend with ahead of the game.
Romelu Lukaku missed the win over Bournemouth after picking up a muscle injury on Friday, and is a doubt to return to the squad.
Antonio Valencia (knee) and Marouane Fellaini (groin) have also been out, and are not expected to return just yet.
Youngster Diogo Dalot is also missing with an unspecified injury, but would not be considered for such a huge game anyway.
Ander Herrera should return to the line-up at the expense of Fred, following a poor performance from the Brazilian on Saturday, and an impressive cameo from the Spaniard.
Marcos Rojo could come into central defence if Mourinho decides to axe either Chris Smalling or Victor Lindelof who are yet to fully gel as a partnership.
With Anthony Martial on fire, Marcus Rashford scoring the winner at Bournemouth, and Alexis Sanchez showing signs of form too, they are the most likely front three.
Jesse Lingard and Juan Mata are also in the picture for a place in the front three – with another conundrum being whether Rashford or Sanchez is the better option as the central striker.
Manchester United’s likely line-up (4-3-3): De Gea; Young, Smalling, Lindelof, Shaw; Herrera, Matic, Pogba; Sanchez, Martial, Rashford.
Whichever formation Boss Mourinho decides to go with,I hope the ‘Old Lady’ will lose against the Red Devils,Its Football after all.